Norfloxacin with itopride versus norfloxacin alone in secondary prophylaxis of spontaneous bacterial peritonitis: a randomized trial

Abstract Background Bacterial translocation is considered the pathophysiological hallmark in development of spontaneous bacterial peritonitis (SBP). Prokinetics can increase gastrointestinal (GIT) motility, reduce small bowel transit time, decrease translocation, and possibility SBP. The aim this work was to compare effectiveness safety itopride norfloxacin versus only secondary prophylaxis for cirrhotic ascitic patients with peritonitis. Results Regarding baseline clinical manifestations laboratory investigations, there no significant difference between both groups. incidence a recurrent SBP group I, who had received plus norfloxacin, reduced than other II (P=0.018). median time recurrence highly longer I (P=0.042). Conclusions combined usage cirrhosis ascites occurrence significantly improve survival patients. Trial registration ClinicalTrials.gov Identifier: NCT04161768 .